One-sample determination of glomerular filtration rate (GFR) in children. An evaluation based on 75 consecutive patients.

AbstractBackground and aim. From a clinical point of view determination of glomerular filtration rate (clearance) is important. The aim of the present study was to compare the one-sample clearance to reference multiple-sample 51Cr-EDTA clearance in consecutively referred children suspected of or with established nephro-urological disorders. Material and methods. A total of 75 children, age ½–13 years, received a quantitative intravenous injection of 51Cr-EDTA followed by six plasma samples 10–120 min after injection. The multiple-sample clearance was measured as injected dose relative to the area under the plasma radioactivity curve. The one-sample clearance was determined from a single plasma sample collected at 60, 90 or 120 min after injection according to the one-pool method. Results. The overall accuracy of one-sample clearance was excellent with mean numeric difference to the reference value of 0.7–1.7 mL/min. In 64 children, the one-sample clearance was within ± 4 mL/min of the multiple-sample valu...