Catalytic Enantioselective Chlorination of Cyclic β‐Keto Esters in the Presence of Chiral Pd(II) Complexes.

Abstract The catalytic enantioselective electrophilic chlorination promoted by chiral palladium complexes is described. The treatment of β-keto esters with 2,3,4,5,6,6-hexachlorocyclohex-2,4-dienone as chlorine source under mild reaction conditions afforded the corresponding α-chlorinated β-keto esters with excellent enantioselectivities (up to 94% ee).