Development of a Total Warning System to Prevent Drug-Interactions Including Injectable Drugs.

A computerized drug-ordering system which includes a warning function to prevent hazardous interactions among all prescription drugs including injections has long been desired. For this purpose, we recently extensively improved our hospital drug-ordering system. This is the first attempt to detect any unfavorable interactions among all drugs including injections.To prevent any undesirable interactions between prescription medicines and injections, we newly registered 60 contraindictory combinations among 500 drugs, 260 medicines and 240 injections, using the “kiri” data base software package. With this system, all possible interactions between any two drugs can be predicted even for separate prescriptions during overlapping administration periods. After starting this new system, 82.3% of inquires by the doctor was associated with injectable drugs. This fact indicates that the drug-interaction checking system between prescription medicines and injections plays an extremely important role in the rational use of drugs.