Correlative Study and Assay of Serum and Cerebrospinal Fluid Neuron-specifice Enolase Concentrations in Patients with Cerebral Infarction

Objective The study aimed to evaluate the clinical value of determinations of neuron-specific enolase concentration in serum and cerebrospinal fluid from patients with acute and recovery cerebral infarction and to find the correlation with neurologic deficits and infarct volume. Methods We measured level neuron-specific enolase of cerebrospinal fluid and serum using an enzyme-linked immunosorbent assay for 46 cases patient group and 25 cases control group. Comparison analyse were performed by using a SPSS10.0 statistical package. Results Patients with acute cerebral infarction are significantly higher than recovery cerebral infarction and control group in the concentration of neuron-specific enolase of serum and cerebrospinal fluid (P0.01). Levels of neuron-specific enolase ofcerebrospinalfluidareasignificantlyhigherthanthatofserum (P0.01). The release of neuron-specific enolase of serum and cerebrospinal fluid in patients were associated with the neurological outcome at discharge from hospital as assessed by Chinese stroke scale scores (P0.01) and the volume of brain lesions (P0.01). Conclusions Our results show that the concentrations of neuron-specific enolase of serum and cerebrospinal fluid in patients with acute cerebral infarction can be a biochemical marker of brain-tissue damage. Measurement of neuron-specific enolase concentration of serum and cerebrospinal fluid in patients may be used as a valuable tools for progrostic parameter of estimating lesion range and clinical stroke treatment.