Pirimidopirimidonas as kinase inhibitors.

A compound of formula: ** (See formula) ** wherein: A is O; B and D are N, and C is CH2; R1 is selected from the group of C1-C6 straight or branched chain, optionally substituted by -COOH, or a) a phenyl, benzyl or C3-C8 cycloalkyl or a -CH2 ring (C3-C8), wherein the rings phenyl, benzyl or cycloalkyl optionally substituted with 1 or 2 groups COOH or CH2-COOH; b) a piperidine or piperazine moiety selected from the group: ** (See formula) ** rings or moieties being optionally piperidine piperazine substituted with 1 or 2 groups COOH or -CH2-COOH; c) a tetrahydropyran or morpholine moiety of the formulas: ** (See formula) ** R2 is H, Cl or F; R3 is H, Cl or F, with the proviso that at least one of R2 or R3 is F; R4 is H, OH, -OCH3, or -OCH2CH3, with the proviso that if R4 is H, R2 and R3 are not H; R5 is -OCH3, or -OCH2CH3; R6 is selected from the group of H, - (C1-C5) -NH2, - (C1-C5) -NH- (C1-C3) -R11, - (C1-C5) -N- (C1 -C3-R11) 2, -O- (C1-C5) -NH2, -O- (C1-C5) -NH- (C1-C3) -R11, -O- (C1-C5) - N- (C1-C3 alkyl-R11) 2, -CH (CH2OH) 2, - (C1-C3) - (CH2OH) - (C1-C3) -O- (C1-C3) -R11, - (C1-C3) -O- (C1-C3) -NH2, - (C1-C3) -O- (C1-C3) -NH- (C1-C3) -R11, - (alkyl C1-C3) -O- (C1-C3) -N (C1-C3-R11) 2, phenyl substituted with 1 or 2 groups selected from NH2, -N (C1-C3), -N (C1 -C3) 2, CN or - (C1-C3) -tetrazole, or C1-C6 alkyl, ** (See formula) ** or ** (See formula) ** each being alkyl chains of any group in the definition of R4 optionally substituted with 1 to 4 OH groups; R7 in each occurrence is independently selected from H, -NH2, NH (C1-C3 ), N (C1-C3) 2, or C1-C3 alkyl; R8 is H, OH or C1-C3 alkyl; R9 is H, OH, NH2, NH (C1-C3), or N (C1-C3) 2; R11 is H, CN, OH, NH2, F, or CF3; or its ester or pharmaceutically acceptable salt.