Optical recording of neural activities of guinea pig auditory cortex in response to sound stimulation

The optical recording method has an advantage over other techniques in that spatiotemporal activity can be monitored. Using this method, neural activities of the guinea pig auditory cortex in response to sound stimulation were recorded. Frequency representation in the auditory cortex was found to be dynamic: the responses were transient and spread and/or propagated along the cortical surface. In order to analyse the dynamic aspects of cortical neural circuitry, inter-columnar interactions of excitation and inhibition were studied by applying glutamatergic and GABAergic receptor antagonists to the cortex. acoustic stimulation/auditory cortex/optical recording/glutamatergic excitation/GABAergic inhibition