Variation in outcomes among 24/7 percutaneous coronary intervention centres for patients resuscitated from out-of-hospital cardiac arrest

Author(s): Mumma, Bryn E; Wilson, Machelle D; Garcia-Pintos, Maria F; Erramouspe, Pablo J; Tancredi, Daniel J | Abstract: BACKGROUND:Patients treated at 24/7 percutaneous coronary intervention (PCI) centres following out-of-hospital cardiac arrest (OHCA) have better outcomes than those treated at non-24/7 PCI centres. However, variation in outcomes between 24/7 PCI centres is not well studied. OBJECTIVES:To evaluate variation in outcomes among 24/7 PCI centres and to assess stability of 24/7 PCI centre performance. METHODS:Adult patients in the California Office of Statewide Health Planning and Development Patient Discharge Database with a "present on admission" diagnosis of cardiac arrest admitted to a 24/7 PCI centre from 2011 to 2015 were included. Primary outcome was good neurologic recovery at hospital discharge. Secondary outcomes were survival to hospital discharge, cardiac catheterisation, and DNR orders within 24 h. Data were analysed using mixed effects logistic regression models. Hospitals were ranked each year and overall. RESULTS:Of 27,122 patients admitted to 128 24/7 PCI centres, 41%25 (11,184) survived and 27%25 (7188) had good neurologic recovery. Adjusted rates of good neurologic recovery (18%25-39%25; p,0.001), survival (32%25-51%25; p l 0.0001), cardiac catheterisation (11%25-49%25; p l 0.0001) and DNR orders within 24 h (4.8%25-49%25; p l 0.0001) varied between 24/7 PCI centres. For the 26 hospitals with mean good neurologic rankings in the top or bottom tenth during 2011-2013, 14 (54%25) remained in their respective tenth for 2014-2015. CONCLUSION:Significant variation exists between 24/7 PCI centres in good neurologic recovery following OHCA and persists over time. Future studies should evaluate hospital-level factors that contribute to these differences in outcomes between 24/7 PCI centres.