Evidence for the secretion of inhibin-like immunoreactivity from cultured human adrenal cells

We have studied the production and release of inhibin-like immunoreactivity in the human adrenal gland. Extract of human adrenal glands showed a displacement curve parallel with the inhibin standard. ACTH stimulated the secretion of inhibin-like immunoreactivity as well as cortisol and aldosterone in a dose- dependent manner in the cultured adrenal cells. These results indicate that the human adrenal gland produces and secretes inhibin-like peptide in response to ACTH