Adverse reactions to tiaprofenic acid mimicking interstitial cystitis

Severe cystitis has been associated with tiaprofenic acid treatment for musculoskeletal pain,*RF 1-3* but this side effect is not well known among urologists, and the potential confusion with interstitial cystitis3 can lead to major surgery being considered or even performed. Case 1 - A 66 year old woman had been prescribed tiaprofenic acid 300 mg twice a day for three years before referral. Other medication included bendro-fluazide 2.5 mg once a day, clonidine hydrochloride 50 μg twice a day, and Codydramol (dihydrocodeine and paracetamol) as needed. She developed frequency and haematuria. Urine culture showed sterile pyuria, cystoscopy a small inflamed bladder, and biopsy interstitial cystitis. She was admitted for ileal conduit formation, but first it was decided to withdraw tiaprofenic acid. …