Генетические маркеры нефротического синдрома у детей

THE AIM of the investigation was to define polymorphism of genes IL-4 in the promoter areas (C-590T) and IL-13 in the 4th exone (G4257A), NPHS1 in the 3rd exone (G349A), NPHS2 in the 5th exone (G755A) in patients with the nephrotic syndrome. PATIENTS AND METHODS. Studying the polymorphic markers of genes IL-4, IL-13, NPHS1 and NPHS2 was carried out in 74 patients with the nephrotic syndrome in the age from 1 through 18 years. All patients were divided into two big groups: the first group – 53 children with the nephrotic syndrome with minimal changes (NSMC) and the second group – 21 patients with focal-segmental glomerulosclerosis (FSGS). RESULTS. The authentic association of polymorphic marker IL-13 with NSMC (χ 2 = 7.64; p<0.05) and polymorphic markers NPHS1 (χ 2 = 6.25; p<0.05) and NPHS2 with FSGS was established (χ 2 = 9.18; p<0.05). CONCLUSION. The research has allowed revealing an association of various genetic markers with NSMC and FSGS and thus the hypothesis was confirmed about various pathogenetic mechanisms in the structure of the morphological forms in question.