Synthesis of novel 1-(7-chloro-6-fluoro-1-benzothiazole-2yl)-3-aryl pyrazole as potential antimicrobial agents

Present work deals with the preparation of 3-aryl-1-(7-chloro-6-fluoro-1-benzothiazole-2yl) pyrazole derivative were prepared from the schiff’s bases of aromatic ketones with dimethyl formamide and phosphorous oxychloride undergo cyclization forming pyrazole derivatives and undergo formylation on to the pyrazole ring. The structure of the synthesized compounds have been established on the bases of spectral (IR, 1HNMR and Mass) Properties and their elemental analyses. Further, these were tested for anti-bacterial activity against S.aureus ATCC 29213, E.coli ATCC 25922, Pseudomonas aeruginosa MTCC 741 and anti-fungal activity against Aspergilus niger ATCC 1015, Candida albicans ATCC 9025 in cup plate method. Evaluation of the compound revealed moderate to good antimicrobial activity.