2 Gene expression in mouse models for multiple sclerosis, Alzheimer's disease and stroke

article i nfo 10 11 Available online xxxx 12 15 Keywords: 16 cDNA microarrays 17 Brain inflammation 18 Cerebral stroke 19 Alzheimer's disease 20 Gene expression profiling 21 The brain responds to injury and infection by activating innate defense and tissue repair mechanisms. Working 22 upon the hypothesis that the brain defense response involves common genes and pathways across diverse pa- 23 thologies, we analysed globalgene expression inbrainfrommousemodels representing threemajor centralner- 24 vous system disorders, cerebral stroke, multiple sclerosis and Alzheimer's disease compared to normal brain