Rifabutin for treating tuberculosis in solid organ transplant recipients: a retrospective observational study and literature review.

BACKGROUND The treatment of tuberculosis (TB) in solid organ transplant (SOT) recipients is challenging due to interactions between rifampin and immunosuppressive drugs. Rifabutin, a rifamycin with excellent activity against Mycobacterium tuberculosis and induces cytochrome p450 less, may facilitate treatment. We report our experience with rifabutin for treating TB in SOT recipients and review the available literature. METHODS A retrospective observational study of all SOT recipients with TB between January 2000 and December 2019. The clinical characteristics and outcomes of patients treated with and without rifabutin-containing regimens were compared and a literature review was conducted. RESULTS We included 31 SOT recipients with TB, among whom 22 (71%) were male and the median age was 62 years (interquartile range 50-20). There were no significant differences between patients treated with rifabutin (n=12), rifampin (n=14), and non-rifamycins (n=5) in clinical cure rates (83.3%, 64.3%,and 100%,respectively; p=0.21), side effects (25%, 37.5%,and 20%, respectively; p=0.74), or mortality (16.7%, 35.7%,and 0%,respectively; p=0.21). Only one patient, treated with rifampin, suffered graft rejection. The literature review identified 59 SOT recipients with TB treated with rifabutin-containing regimens from 8 publications. Overall, the clinical cure, graft rejection, and mortality rates were 93.2%, 5.1%, and 5.1%, respectively. CONCLUSIONS Rifabutin-containing regimens offer a reliable alternative to rifampin when treating TB in SOT recipients.