EP427 Comparison of survival curves according to pronostic risk fatcors in patients with early-stage cervical cancer (ESCC)

Introduction/Background To determine the impact of prognostic risk factors on survival of patients with ESCC. Methodology Overall survival was analysed by using Kaplan-Meier analysis and compared by applying log-rank test. Results 61 patients with ESCC who underwent surgery as primary treatment were included. We obtained an overall survival of 100% and 97.7% in the first year and up to 5 years of follow-up. Prognostic factors were: TNM and FIGO stage, tumor size, LVSI, depth of cervical stroma invasion, involvement of parametrium, positive surgical margin and lymph node involvement. When comparing the survival curves for each prognostic factor individually, only a statistically significant association was observed for ‘surgical margin affected’ (p=0.008). No other significant association was observed. A trend towards statistical significance is observed if we group several prognostic factors. Hence, the coexistence of ≥3 risk factors reaches almost the level of significance (p=0.06). Adjuvant radio-chemotherapy was given to 20/57(35%) patients. Among them 65% presented associated morbidity: 30%digestive, 30%cutaneous, 25%haematological and 15%urological. The morbidity was severe in one case, moderate in5/13 and mild in the remained cases (7/13). Conclusion Accurate pre-surgical staging would properly select surgical candidates and avoid radio-chemotherapy. Indications for adjuvant treatment should be reconsidered. LVSI as an independent risk factor is controversial and questionable. Disclosure Nothing to disclose.