Release of Antidiuretic Hormone Due to Common Carotid Occlusion and Its Relation with Vagus Nerve.

SummaryIn bilaterally vagotomized dogs, occlusion of common carotid arteries caused an increase in plasma ADH concentration, which averaged 264% of control at 2 minutes after beginning the occlusion. This increase in ADH was not observed in normal dogs with vagi intact or in dogs with efferent vagi blocked by atropine. It is concluded that the afferent vagal fibers exert some inhibitory influence on the supraoptico-hypophyseal system and that carotid occlusion results in ADH release when the vagal inhibition is removed.