Is the response of continuous glucose monitors to physiological changes in blood glucose levels affected by sensor life

Abstract Background: None of the studies concerned with the performance of a continuous glucose monitor (CGM) over time has examined the extent to which extended periods of wear affect the responses of both CGM accuracy and lag time to rapid changes in blood glucose levels. Here we propose a novel approach to address these issues. Methods: Eight participants without diabetes were each fitted with two CGMs (Paradigm® 722 Real-Time [Medtronic, Northridge, CA]; abdominal and triceps regions) and completed fasted oral glucose challenges (OGCs) on six occasions over a 9-day period, while the CGMs were worn without removal. Arterialized blood samples were collected for comparison with CGM values. Results: There were marked mismatches and lag times between blood glucose and CGM values in response to all OGCs, most notably during the initial rapid increase in glucose levels. Abdominal and triceps CGMs consistently underestimated peak blood glucose by an average of 2.7±0.2 and 2.9±0.2 mM, respectively, and were as...