Accurate detection of atrial fibrillation from 12-lead ECG using deep neural network

Abstract Atrial fibrillation (AF) is the most common heart arrhythmia, and 12-lead electrocardiogram (ECG) is regarded as the gold standard for AF diagnosis. Highly accurate diagnosis of AF based on 12-lead ECG is valuable and remains challenging. In this paper, we proposed a novel method with high accuracy for AF detection based on deep learning. The proposed method constructed a novel one-dimensional deep densely connected neural network (DDNN) to detect AF in ECG waveforms with a length of 10s. A large set of 16,557 12-lead ECG recordings collected from multiple hospitals and wearable ECG devices were used to evaluate the performance of the DDNN. In the test dataset (3,312 12-lead ECG recordings), the DDNN obtained high performance with an accuracy of 99.35 ± 0.26%, a sensitivity of 99.19 ± 0.31%, and a specificity of 99.44 ± 0.17%. Its high performance and automatic nature both demonstrate that the proposed network has a great potential to be applied to clinical computer-aided diagnosis of AF or future screening of AF in wearable devices.