The pilus and porin of Neisseria gonorrhoeae cooperatively induce Ca2+ transients in infected epithelial cells

Summary Purified pili and porin from Neisseria quickly mobilize calcium (Ca 2 + ) stores in monocytes and epithelial cells, ultimately influencing host cell viability as well as bacterial intracellular survival. Here, we examined the Ca 2 + transients induced in human epithelial cells during infection by live, piliated N. gonorrhoeae . Porin induced an influx of Ca 2 + from the extracellular