Oscillating potentials of the electroretinogram in the evaluation of the effects of padma 28 on lipid metabolism and vascular changes in humans

In this study the effect of Padma 28 on lipid parameters and oscillating potentials of the electroretinogram in humans was measured. The aim of the study was to determine whether a correlation between disturbances in lipid metabolism and oscillating potentials exists. The lipid parameters studied in blood serum of patients included: triglycerides, total cholesterol and HDL cholesterol percentage. A decrease in the amplitudes of oscillating potentials was observed in patients with hyperlipidaemia, including both hypercholesterolaemia and hypertriglyceridaemia. In these patients, after 16 weeks of treatment with Padma 28 the values for oscillating potentials and lipid parameters normalized. Thus the oscillating potentials of the electroretinogram may prove a useful tool in diagnosing pathological conditions that are associated with disturbances in blood lipid levels, such as atherosclerosis, at early stages hitherto difficult to diagnose.