Subcellular functional specificity of dynein-dynactin complex subunits - normal distribution and disturbances in neurodegenerative disease
2006
Cytoplasmic dynein and its activating complex dynactin drive the retrograde transport of material necessary for the survival and proper functioning of neurons. Disruption of the dynein-dynactin complex by either over-expression of the dynamitin subunit or by mutations within individual dynein/dynactin subunits can cause motor neuron degeneration.
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