Metabolic regulator LKB1 is crucial for Schwann cell-mediated axon maintenance

Axonal maintenance is known to rely, in part, on non-cell-autonomous support from myelinating glia, but the mechanisms are still unclear. In this study, the authors show that loss of the serine/threonine kinase LKB1 in Schwann cells leads to changes in nerve metabolism and axonal degeneration, even in the absence of demyelination.