Some Application of Selective Toxicities of Acridines

Inhibitions of pathogen specific enzymes with acridines play roles in cure of various diseases. Thus, acridines can serve for treatment of various tropical diseases caused by protozoal parasites e.g. African sleeping sickness, antibacterial agents for combating e.g. tuberculosis, antiviral agent for combating HIV. Moreover, interactions with immune system can overcome failure of human immune system suppressing either cancer or massive autoimmune response. In this chapter, we briefly describe the role of acridines in fight with tropical diseases, cancer, and bacterial infections.