The value of PAPP-A in the diagnosis and prognosis of GTD

Abstract Objective To investigate the value of PAPP-A (pregnancy assouated plasma protein-A) in the diagnosis and prognosis of gestational trophoblastic disease (GTD). Methods The serum β-HCG(β-human chorionic gonadotropin) and PAPP-A levels of 25 normal pregnant women, 28 patients with complete hydatidiform mole and 38 patients with invasive mole were measured by enzyme linked immunosorbent assay (ELISA) during the periods of diagnosis, treatment and follow-up. Results Compared with control group, patients with complete mole and invasive mole had higher levels of β-HCG ( P P > 0.05). The PAPP-A level of complete mole group was significantly higher than that of control group ( P P P Conclusion The PAPP-A level can give us some help not only in early diagnosis of hydatidiform mole and invasive mole, but also in the prognosis of malignant sequelae.