Regulatory peptides and the onset of nausea and vomiting

There is no direct evidence that peptide hormones mediate vomiting observed during various cardiovascular, cerebrovascular, visceral, or neurological disorders. On the other hand, recent studies in animal models have demonstrated that several endogenous vasoactive neuropeptides can induce short-latency emesis following systemic or intracranial injections. This article reviews experimental data on peptide-induced emesis.Key words: emesis, neuropeptides, area postrema, angiotensin II, vasopressin.