Influence of gender in predicting CCR5 coreceptor usage

Methods Viral tropism was determined in 98/116 (84%) (ViroLogic PhenoSense assay). Viral tropism was classified as R5, D/M or X4 for virus that used CCR5 coreceptor, CCR5 and CXCR4 coreceptors or CXCR4 coreceptor, respectively. Variables evaluated for the association with the R5 virus (outcome variable) were: age, gender, CDC stage (C vs. A and B), screening CD4 percentage, CD4+ cells, HIV1 plasma RNA level, nadir CD4+, risk factor (IVDU vs. other), time since HIV infection. All these characteristics were considered at univariable and multivariable analysis. Logistic regression was applied at multivariable analysis. Data were described as median (Q1–Q3) or frequency (%), as appropriate.