Study on ingredients in decoction of Psoralea corylifolia L. through placental barrier of rats in pregnancy

Objective:To study the ingredients in decoction of Psoralea corylifolia L.through placental barrier of rats at different stages of pregnancy by HPLC.Methods:The pregnant rats were administered decoction of Psoralea corylifolia L.(2.7g/kg) for 5 days at different stages of pregnancy,including first,second and third trimester.Plasma and embryonic tissues were obtained after 12h of the final administration.The componds in biological specimen were identified by HPLC.Results:Psoralenoside,isopsoralenoside,psoralen,isopsoralen were detected in plasma and the first and third trimester embryonic tissues.At the second trimester of pregnancy,psoralen and isopsoralen were detected in the embryonic tissues.Conclusion:Psoralenoside,isopsoralenoside,psoralen,isopsoralen could be transported through placental barrier.It suggested we should pay more attention on the safety using Psoralea corylifolia L.in pregnancy.