Methylprednisolone Delivery by Hyalobend® Corneal Shields and its Effects on Rabbit Ocular Inflammation

ABSTRACT Release of methylprednisolone from hyaluronic acid derivative corneal shields (Hyalobend®), in vitro and in vivo, was evaluated as well as ocular anti-inflammatory activity in the rabbit eye. The release of methylprednisolone from Hyalobend® corneal shields in vitro followed zero-order kinetics. After placing Hyalobend® corneal shields in rabbit eye, aqueous and tear fluid methylprednisolone levels were detected up to 48 hours and compared with the levels obtained with methylprednisolone suspension. Hyalobend® corneal shields maintain almost constant methylprednisolone levels in the rabbit tear fluid. On the contrary, the suspension gave very high tear values of steroid concentrations in the first 30 minutes but undetectable in less than 200 minutes. Hyalobend® corneal shields ensured effective levels of methylprednisolone into the rabbit aqueous for up to 48 hours. Aqueous levels of drug, in the group treated with the suspension, decreased progressively and after 480 minutes were undetectable. H...