Korean Medication Algorithm Project for Generalized Anxiety Disorder 2009 (III) : Treatment Strategy for Comorbid Conditions

Objectives This study investigated the consensus about treatment strategies for comorbid conditions in generalized anxiety disorder (GAD). Methods The executive committee of the Korean Medication Algorithm Project for GAD developed questionnaires about treatment strategies for patients with panic disorder based on guidelines or algorithms and clinical trial studies previously published in foreign countries. This study analyzed the treatment strategies for comorbid conditions in GAD. Fifty-five (65%) of 84 experts on a committee reviewing GADs responded to the questionnaires. We classified the consensus of expert opinions into three categories (first-line, second-line, and third-line treatment strategies) and identified the treatment of choice according using a test and 95% confidence interval. Results The consensus about treatment strategies in the case of GAD with comorbid depression recommended a selective serotonin re-uptake inhibitor (SSRI) and a serotonin norepinephrine re-uptake inhibitor (SNRI) as the first-line drug treatment. An SSRI, an SNRI and a benzodiazepine (e.g. alprazolam, clonazepam) are recommended in GAD patients with other comorbid anxiety disorders. Conclusion This study provided information about the consensus among Korean experts with regard to treatment strategies for comorbid conditions of GAD.