Фармакологічна протекція органів на донорському етапі

Study objective . To evaluate the effectiveness of the developed scheme HRT PD and pharmacological protection of organs at the stage of explantation, with further assessment of graft function in the early postoperative period. Materials and methods. It was conducted that a randomized, prospective, single-center study aimed to determine the effectiveness of the proposed HRT (methylprednisolone, levothyroxine, insulin, metformin, desmopressin) at the stage of PD conditioning with the use of pharmacological agents: heparin, streptokinase, ebrantil during explantation of 80 potential donors with brain death and basing on the results of 144 kidney transplants. Study results. It was statistically proved that the need in a vasopressors dose were reduced, basal metabolism and heat production were enhancing of all the patients treated with HRT when PD conditioning on the donor phase. The use of pharmacological protection improves metabolic and electrolyte performance effluent after donor kidney flushing. Reliably significantly increased the number of multiorgan donors retrievals and primary functioning kidney transplant compared to the control group. Conlusion . Usage of the HRT therapy and donor organs' pharmacological protection suggested by the authors improves the quality of potential donors conditioning during a kidney transplant.