Impact of late presentation of HIV infection on short-, mid- and long-term mortality and causes of death in a multicenter national cohort: 2004–2013

Summary Objectives To analyze the impact of late presentation (LP) on overall mortality and causes of death and describe LP trends and risk factors (2004–2013). Methods Cox models and logistic regression were used to analyze data from a nation-wide cohort in Spain. LP is defined as being diagnosed when CD4  Results Of 7165 new HIV diagnoses, 46.9% (CI 95% :45.7–48.0) were LP, 240 patients died. First-year mortality was the highest (aHR LP.vs.nLP  = 10.3[CI 95% :5.5–19.3]); between 1 and 4 years post-diagnosis, aHR LP.vs.nLP  = 1.9(1.2–3.0); and >4 years, aHR LP.vs.nLP  = 1.5(0.7–3.1). First-year's main cause of death was HIV/AIDS (73%); and malignancies among those surviving >4 years (32%). HIV/AIDS-related deaths were more likely in LP (59.2% vs. 25.0%; p  Factors associated with LP: sex (OR MEN.vs.WOMEN  = 1.4[1.2–1.7]); age (OR 31–40.vs.  = 1.6[1.4–1.8], OR 41–50.vs.  = 2.2[1.8–2.6], OR >50.vs.  = 3.6[2.9–4.4]); behavior (OR InjectedDrugUse.vs.MSM  = 2.8[2.0–3.8]; OR Heterosexual.vs.MSM  = 2.2[1.7–3.0]); education (OR PrimaryEducation.vs.University  = 1.5[1.1–2.0], OR LowerSecondary.vs.University  = 1.3[1.1–1.5]); and geographical origin (OR Sub - Saharan.vs.Spain  = 1.6[1.3–2.0], OR Latin-American.vs.Spain  = 1.4[1.2–1.8]). Conclusions LP is associated with higher mortality, especially short-term- and HIV/AIDS-related mortality. Mid-term-, but not long-term mortality, remained also higher in LP than nLP. LP decreased in MSM and heterosexual men, not in heterosexual women. The groups most affected by LP are low educated, non-Spanish and heterosexual women.