HLA-DRB1 * 15与162例儿童急性淋巴细胞白血病发病的关系

To unravel the relation of HLA-DRB1*15 with childhood acute lymphoblastic leukemia (ALL), 162 childhood patients with ALL were selected for this investigation. 1000 normal umbilical cord blood samples were used as control. HLA-DRB1*15 and HLA-DRB5*were typed by ploymerase chain reaction (PCR) analysis. The relation of HLA-DRB1*15 with childhood ALL was studied by calculating the chi-square test and relative risk. The results showed that the antigen frequencies and allele frequencies of HLA-DRB1*15 in childhood patients with ALL were 40.12% and 22.62% respectively, while the antigen frequencies and allele frequencies of HLA-DRB1*15 in control were 30.80% and 16.81% respectively, there were significant difference between them (χ^2=5.560, p=0.018, RR=1.506). In conclusion, the antigen frequencies and allele frequences of FILA-DRB1*15 in childiood patients with ALL were higher than those in control, so the HLA-DRB1*15 gene is one of the genetic risk factors for childhood ALL. These preliminary data may be useful for further study on the pathogenesis of childhood ALL.