Optical active tetrahydropyridine derivative and preparation method thereof

The invention relates to an optical active tetrahydropyridine derivative and a preparation method thereof. The preparation method includes steps of taking aldehyde, amine and Beta-keto acid ester as raw materials and chiral phosphoric acid as a catalyst to react in an organic solvent for 24-120 hours at a temperature of -50-50 DEG C on the condition of presence of a molecular sieve, and obtaining optical active tetrahydropyridine derivative via purification separation. The method for tetrahydropyridine derivative is mild in reaction conditions, simple in technique and convenient and rapid to operate.Furthermore, the optical active tetrahydropyridine derivative is capable of serving as an intermediate of medicament synthesizing, and has potentially good bioactivity.