Can the selective PDGF-receptor antagonist STI571 reduce hypoxia in solid tumors, and enhance drug uptake of Taxol, by lowering the interstitial fluid pressure in stroma rich breast carcinoma, BT-474

Marcus Runeson

Can the selective PDGF-receptor antagonist STI571 reduce hypoxia in solid tumors, and enhance drug uptake of Taxol, by lowering the interstitial fluid pressure in stroma rich breast carcinoma, BT-474

2015

Marcus Runeson

Background Solid tumors have high interstitial fluid pressure, IFP. This cause a dramatic loss in uptake of anti cancer drugs with poor clinical outcome as result. Treatment with PDGF-receptor anta ...

Keywords:

Stroma
Interstitial fluid
Cancer
Carcinoma
Cancer research
Immunology
Biology
Hypoxia (medical)
Platelet-derived growth factor receptor
anti cancer drugs
Antagonist
breast carcinoma
drug uptake
Pathology
interstitial fluid pressure

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