Morphological alterations and increase of S-100 protein in cultured human glioma cells deprived of serum

Abstract Morphological alterations accompanied by an increase of the glia-specific protein S-100 have been shown to occur in a glial cell line (138 MG) of a human brain tumour if serum is removed from the culture medium. The glial S-100 protein was immunologically indistinguishable from S-100 present in human brain.