ProteoPlex: stability optimization of macromolecular complexes by sparse-matrix screening of chemical space

Ashwin Chari,David Haselbach,Jan-Martin Kirves,Juergen Ohmer,Elham Paknia,Niels Fischer,Oleg M. Ganichkin,Vanessa Möller,Jeremiah J. Frye,Georg Petzold,Marc A. Jarvis,Michael Tietzel,Clemens Grimm,Jan-Michael Peters,Brenda A. Schulman,Kai Tittmann,Jürgen Markl,Utz Fischer,Holger Stark

ProteoPlex: stability optimization of macromolecular complexes by sparse-matrix screening of chemical space

2015

Ashwin Chari
David Haselbach
Jan-Martin Kirves
Juergen Ohmer
Elham Paknia
Niels Fischer
Oleg M. Ganichkin
Vanessa Möller
Jeremiah J. Frye
Georg Petzold
Marc A. Jarvis
Michael Tietzel
Clemens Grimm
Jan-Michael Peters
Brenda A. Schulman
Kai Tittmann
Jürgen Markl
Utz Fischer
Holger Stark

ProteoPlex optimizes buffer conditions for the isolation and purification of macromolecular complexes. The concurrent complex stabilization is beneficial for structure determination using X-ray crystallography or cryo-electron microscopy.

Keywords:

Molecular biophysics
Protein structure
Macromolecular Complexes
Sparse matrix
Chemical space
Protein folding
X-ray crystallography
Microscopy
Bioinformatics
Biology

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