Highly enantioselective hydrogenation of enamides catalyzed by rhodium-monodentate phosphoramidite complex derived from H8-BINOL

Xingshu Li,Xian Jia,Gui Lu,Terry T.-L. Au-Yeung,Kim-Hung Lam,Thomas Wai Hung Lo,Albert S. C. Chan

Highly enantioselective hydrogenation of enamides catalyzed by rhodium-monodentate phosphoramidite complex derived from H8-BINOL

2003

Xingshu Li
Xian Jia
Gui Lu
Terry T.-L. Au-Yeung
Kim-Hung Lam
Thomas Wai Hung Lo
Albert S. C. Chan

Abstract A series of monodentate phosphoramidite ligands derived from H 8 -BINOL have been synthesized. The ligands are used in the Rh-catalyzed asymmetric hydrogenation of enamides to give the acetamides in up to 99% ee.

Keywords:

Stereochemistry
Enantioselective synthesis
Rhodium
Catalysis
Organic chemistry
Denticity
Chemistry
Photochemistry
Asymmetric hydrogenation
Ligand
Phosphoramidite

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