Low Power Photodynamic Therapy for Retinoblastoma Mediated by Reactive Oxidative Damage

Retinoblastoma(RB) is the most common primary intraocular malignancy of infancy,traditional chemotherapy or brachytherapy may induce secondary sarcoma.Photodynamic therapy(PDT),a non-invasive selective therapy may be preferable.In this study,we observed the photodynamic effect of different dosages of PPa on Y79 cells through detecting the ROS production and corresponding cell apoptosis.The results indicated that the ROS production and corresponding cell apoptosis ratio increased obviously with an escalating PPa dosage(0.2、0.4、 0.6 μmol/L),it is a primary proof of the feasibility of PPa-based photodynamic therapy for retinoblastoma cells killing.