Hypolipidemic and antioxidant ef fects of phytochemical compounds against hepatic steatosis induced by high fat high sucrose diet in rats

The global feeding on Western diet, which is enrich ed in fat and fructose, has been proposed to be a c ause of metabolic disorder, including hepatic steatosis whi ch is associated with oxidative stress. In the pres ent study, we investigated the influence of co-treatment with phytochemical compounds, quercetin (Q), o-coumaric (CA) and berberine (BB) on the hepatic lipid profil e and oxidative stress markers of rats fed a HFS di et. Rats fed HFS diet showed hypertriglycemia, hypercholesterolemia, and alteration of oxidative markers in hep atic tissues and serum and histological changes in liver tissues. Supplementing a HFS diet with CA and BB ameliorates hypertriglycemia, hypercholesterolemia and oxidative stress biomarkers. However, Q improved the biochemical changes in lipid profile and oxidat ive stress, but failed to improve the histological changes in liver tissue. In conclusion, the present results ev idences indicate that CA and BB could be considered as promising complementary treatments against hepatic steatosis development associated with HFS.