Analysis of the distribution and drug-resistance of Pseudomanas aeruglnosa in hospital infection

Objective To investigate the distribution and drug-resistance of Pseudomonas aeruginosa (PA) in hospital infection, and to provide the experimental evidence for clinical therapy. Methods The clinical specimens were collected from Jan 2006 to Dec 2007. Identification of the bacteria and Antimicrobial susceptibility test were performed on VITEK·TWO all-automatic microbiology analysis system. Results Lung was the main infected organ of PA. PA showed cross-resistance to multiple antibiotics. Antimicrobial susceptibility test showed that the sensitive rates of PA to Aztreonam, Ticarcillin/Tazobactam, Cefoperazone, Gentamycinand Tobramycin were lower than 60.0％ ; and the sensitive rates to Meraopenem, Levofloxacin, Imipenem, Ciprofloxacin were 83.0％,79.2％,76.9％75.9％respectively. Conclusion PA is muhi-rosistant to most antimicrobial agents. In the treatment of clinical PA infection ,drugs should be selected according to the results of antimicrobial susceptibility test. Key words: Pseudomonas aeruginosa; Hospital infection; Drug-resistance