Phthalides and Other Metabolites from Roots of Ligusticum wallichii

A new phthalide that was identified using NMR and mass spectral data as (±)-3-methoxysedanenolide (1) and the nine known compounds sedanenolide (2), Z-ligustilide (3), Z-butylidenephthalide (4), methyl ferulate (5), trans-ferulic (6) and trans-isoferulic acids (7), falcarindiol (8), β-sitosterol (9), and daucosterol (10) were isolated from the MeOH extract of roots of Ligusticum wallichii. Compounds 7 and 8 exhibited high inhibitory activity against NO formation in RAW264.7 cells.