Glycyrrhetinic acid modifier with antitumor activity and preparation method thereof

The invention relates to a glycyrrhetinic acid modifier with antitumor activity and a preparation method thereof, which relate to structural modification technology of glycyrrhetinic acid. The method comprises the following step that: after carrying out esterification on 30-bit carboxyl and alkyl chloride of the glycyrrhetinic acid, modifying an A loop to realize structural modification of the glycyrrhetinic acid so as to obtain a series of glycyrrhetinic acid derivatives (I 1-5, I I1-5, III 1-5, IV 1-5 and V1-5). Through a test, the glycyrrhetinic acid modifier has a certain inhibiting effect for human body cervical carcinoma HeLa cells, hepatocelular carcinoma HepG2 cells and gastric cancer BGC-823 cells. The structure of the glycyrrhetinic acid derivatives is shown in the description.