Comparison of lacosamide versus sodium valproate in status epilepticus: A pilot study.

Abstract Purpose The purpose of this study was to compare the efficacy and safety of lacosamide (LCM) and sodium valproate (SVA) in lorazepam (LOR)-resistant SE. Methods Patients with LOR-resistant SE were randomized to intravenous LCM 400mg at the rate of 60 mg/kg/min or SVA 30 mg/kg at the rate of 100 mg/min. The SE severity score (STESS), duration of SE and its etiology, and MRI findings were noted. Primary outcome was seizure cessation for 1 h, and secondary outcomes were 24 h seizure remission, in-hospital death, and severe adverse events (SAE). Results Sixty-six patients were included, and their median age was 40 (range 18–90) years. Thirty-three patients each received LCM and SVA. Their demographic, clinical, STESS, etiology, and MRI findings were not significantly different. One-hour seizure remission was not significantly different between LCM and SVA groups (66.7% vs 69.7%; P = 0.79). Twenty-four-hour seizure freedom was insignificantly higher in SVA (20, 66.6%) compared with LCM group (15, 45.5%). Death (10 vs 12) and composite side effects (4 vs 6) were also not significantly different in LCM and SVA groups. LCM was associated with hypotension and bradycardia (1 patient), and SVA with liver dysfunction (6). Conclusion In patients with LOR-resistant SE, both LCM and SVA have comparable efficacy and safety.