Varis dışı akut üst gastrointestinal sistem kanamalı hastalardalökositoz ile kanama ciddiyeti arasındaki ilişki

Background and Aims:Many studies have investigated the correlation between laboratory parameters checked at presentation to the hospital and the severity of bleeding in patients with acute non-variceal upper gastrointestinal system bleeding. In this study, we investigated the predictive value of leukocytosis determined at presentation to the hospital in predicting the severity of bleeding. Materials and Methods: Patients presenting to the emergency polyclinic of Haydarpasa Numune Training and Research Hospital between 2006 and 2010 with the complaint of hematemesis and/or melena and admitted to the Internal Medicine Clinic due to upper gastrointestinal system bleeding with the detection of melena and/or hematemesis were included in the study. Collection of demographic data, upper gastrointestinal endoscopy findings, and pathological results of biopsies taken during the endoscopy was performed retrospectively. Only leukocyte values determined at presentation to the emergency polyclinic were taken into consideration.Results: Statistically significant differences were determined between the groups regarding the number of leukocytes (p: 0,007), number of platelets (p: 0,039), blood urea nitrogen levels (p: 0,000), albumin levels (p: 0,006), requirement for erythrocyte suspension replacement (p: 0,040), and requirement for fresh frozen plasma replacement (p: 0,045). Conclusions:The close association between leukocytosis and the markers of severe bleeding, such as blood urea nitrogen, requirement for erythrocyte suspension and fresh frozen plasma and hypoalbuminemia, shows that leukocytosis can be used as a parameter to help predict the severity of the clinical course at presentation to the emergency polyclinic. The inability to determine a significant difference between the hospitalization periods can be attributed to the small numbers of patients in our study. It seems that future studies performed in large patient series will facilitate leukocytosis taking its place among the clinical scoring systems used for upper gastrointestinal system bleedings.