Synthesis of clickable amphiphilic polysaccharides as nanoscopic assemblies.

Liye Fu,Lingyao Li,Jun Wang,Kyle Knickelbein,Lin Zhang,Ian Milligan,Yi Xu,Kylie O'Hara,Lindsay Bitterman,Wenjun Du

Synthesis of clickable amphiphilic polysaccharides as nanoscopic assemblies.

2014

Liye Fu
Lingyao Li
Jun Wang
Kyle Knickelbein
Lin Zhang
Ian Milligan
Yi Xu
Kylie O'Hara
Lindsay Bitterman
Wenjun Du

The synthesis of clickable polysaccharides was achieved by using alkynylated 1,6-anhydro glucopyranose as a monomer and BF3·OEt2 as an effective catalyst. Subsequent click conjugation with polyethylene glycol (PEG) afforded PEG-grafted polysaccharides in nearly quantitative efficiency.

Keywords:

Combinatorial chemistry
PEG ratio
Click chemistry
Clickable
Polyethylene glycol
Polysaccharide
Nanoscopic scale
Monomer
Chemistry
Organic chemistry
Amphiphile

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