Green Synthesis of Zinc Oxide Nanoparticles (ZnO NPs) Using Cissus quadrangularis: Characterization, Antimicrobial and Anticancer Studies

In the present study, zinc oxide nanoparticles (ZnO NPs) were synthesized using the stem aqueous extracts of Cissus quadrangularis (Cq) and characterized using UV, FTIR, XRD, TEM, SAED and EDAX. The synthesized Cq-ZnO NPs showed its optical absorbance at 378 nm and observed as spherical particles with a size of about ~ 75 to 90 nm. The potential antibacterial activity of Cq-ZnO NPs showed an effective inhibition of M. smegmatis at 50 µg/ml when compared to other bacterial species. The antiproliferative effect was observed at 100 μg/ml on MIA PaCa-2 cell lines with IC50 value of 7.02 ± 0.02 µg/ml at 24 h. The synthesized Cq-ZnO NPs was found potential activity against bacterial pathogens and cancer cells. Therefore, they may possibly be employed as useful antibacterial and antiproliferative agents.