MP173 THE GERMAN CYLCIPHYLAXIS REGISTRY

Introduction and Aims: Cardiovascular events are frequent and vascular endothelial function is abnormal in patients with chronic kidney disease (CKD). We previously demonstrated endothelial dysfunction with vitamin D deficiency in CKD patients; however the impact of vitamin D supplementation on vascular function is unknown. This study examined the effect of cholecalciferol supplementation on vascular function and circulating biomarkers in non-diabetic, CKD patients with low vitamin D. Methods: We assessed patients with CKD stage 3/4, aged 17-80 years and 25-hydroxy vitamin D concentrations <75 nmol/L, in the absence of diabetes, malignancy, infection, heart failure, autoimmune disease, hypercalcaemia, vitamin D treatment, recent MI or CVA. Flow mediated dilation (FMD) of the brachial artery, pulse wave velocity and circulating blood biomarkers were evaluated at baseline and at 16 weeks. 300,000 units of cholecalciferol were administered at baseline and at 8-week follow up. Results: Clinical characteristics of 26 recruited patients were: age 50±14 years, eGFR 41 ±11 ml/min/1.73m 2 , males 73%, dyslipidaemia 36%, smokers 39% and hypertensives 87%. At 16-week follow up vitamin D and calcium levels increased (43±16 to 84±29