Synthesis and Evaluation of Indole-Based Autoinducers on Quorum Sensing in Vibrio cholerae.
2020
Vibrio cholerae (V. cholerae) uses the autoinducer CAI-1 (cholera autoinducer
1) and several linked quorum sensing systems in order to efficiently
sense its ever-changing environment and optimally coordinate population-wide
gene expression. Indole has been reported as an important signal that
is sensed by V. cholerae, and here, we report the
synthesis and evaluation of a focused library of synthetic indole–CAI-1
derivatives as tools to probe quorum sensing (QS) in this human pathogen.
Our results show interesting and diverging effects for several conjugates,
as compared to CAI-1, on virulence factor production and biofilm formation.
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