Effect of a high-fat meal on the relative bioavailability of H3B-6527, a novel FGFR4 inhibitor, in healthy volunteers
2019
Purpose
This Phase I study estimated the effect of a high-fat meal on the pharmacokinetics (PK) of H3B-6527, a covalent inhibitor of the fibroblast growth factor receptor (FGFR) 4 in clinical development for hepatocellular carcinoma and intrahepatic cholangiocarcinoma.
Keywords:
- Fibroblast growth factor receptor
- Pharmacology
- Hepatocellular carcinoma
- Meal
- Fibroblast growth factor receptor 4
- Bioavailability
- Intrahepatic Cholangiocarcinoma
- Medicine
- FOOD EFFECT
- Pharmacokinetics
- Crossover study
- Cmax
- Confidence interval
- Liquid chromatography–mass spectrometry
- Endocrinology
- Internal medicine
- Tolerability
- Correction
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- Cite
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