The screening method of the low-molecular-weight compounds that bind to the antibody

The present invention aims to provide a method for easily screened a low molecular weight compound having the ability to bind to antibodies in silico. Methods of screening small molecule compounds that bind to the antibody of the present invention in the variable region of the light chain of the antibody, the first and the binding target site contained in a framework region having an amino acid sequence 1, the heavy chain of the antibody in the variable region, for both the second binding target site contained in a framework region having an amino acid sequence 2, characterized in that it comprises a step of selecting compounds exhibiting low docking scores in the docking simulation.