Ontogenetic Development of the Specific [3H]Nitrendipine Binding Sites in the Rat Whole Brain

Ca ion channel antagonists have been attracting much attention as therapeutic drugs for cardiovascular disorders such as angina pectoris and hypertension, especially from the viewpoint of pharmacological mechanism. Recently, through Ehlert and Itoga’s experiments, the Ca ion channel antagonist was confirmed to bind specifically, not only to vascular smooth muscle but also to gastrointestinal smooth muscle and even to the neuron itself (1). This broke new ground in the study of the pharmacological action of Ca ion channel antagonists.